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Page 1
Acetyl-methyllysine marks chromatin at active transcription start sites.
Lu-Culligan WJ, Connor LJ, Xie Y, Ekundayo BE, Rose BT, Machyna M, Pintado-Urbanc AP, Zimmer JT, Vock IW, Bhanu NV, King MC, Garcia BA, Bleichert F, Simon MD. Lu-Culligan WJ, et al. Among authors: zimmer jt. Nature. 2023 Oct;622(7981):173-179. doi: 10.1038/s41586-023-06565-9. Epub 2023 Sep 20. Nature. 2023. PMID: 37731000 Free PMC article.
Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies.
Biancon G, Joshi P, Zimmer JT, Hunck T, Gao Y, Lessard MD, Courchaine E, Barentine AES, Machyna M, Botti V, Qin A, Gbyli R, Patel A, Song Y, Kiefer L, Viero G, Neuenkirchen N, Lin H, Bewersdorf J, Simon MD, Neugebauer KM, Tebaldi T, Halene S. Biancon G, et al. Among authors: zimmer jt. Mol Cell. 2022 Mar 17;82(6):1107-1122.e7. doi: 10.1016/j.molcel.2022.02.025. Mol Cell. 2022. PMID: 35303483 Free PMC article.
ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control.
Gao Y, Zimmer JT, Vasic R, Liu C, Gbyli R, Zheng SJ, Patel A, Liu W, Qi Z, Li Y, Nelakanti R, Song Y, Biancon G, Xiao AZ, Slavoff S, Kibbey RG, Flavell RA, Simon MD, Tebaldi T, Li HB, Halene S. Gao Y, et al. Among authors: zimmer jt. Cell Rep. 2023 Oct 31;42(10):113163. doi: 10.1016/j.celrep.2023.113163. Epub 2023 Sep 23. Cell Rep. 2023. PMID: 37742191 Free PMC article.
Functional elements of the cis-regulatory lincRNA-p21.
Winkler L, Jimenez M, Zimmer JT, Williams A, Simon MD, Dimitrova N. Winkler L, et al. Among authors: zimmer jt. Cell Rep. 2022 Apr 19;39(3):110687. doi: 10.1016/j.celrep.2022.110687. Cell Rep. 2022. PMID: 35443176 Free PMC article.
Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape.
Boddu PC, Gupta AK, Roy R, De La Peña Avalos B, Olazabal-Herrero A, Neuenkirchen N, Zimmer JT, Chandhok NS, King D, Nannya Y, Ogawa S, Lin H, Simon MD, Dray E, Kupfer GM, Verma A, Neugebauer KM, Pillai MM. Boddu PC, et al. Among authors: zimmer jt. Mol Cell. 2024 Apr 18;84(8):1475-1495.e18. doi: 10.1016/j.molcel.2024.02.032. Epub 2024 Mar 22. Mol Cell. 2024. PMID: 38521065
Targeted Degradation of mRNA Decapping Enzyme DcpS by a VHL-Recruiting PROTAC.
Swartzel JC, Bond MJ, Pintado-Urbanc AP, Daftary M, Krone MW, Douglas T, Carder EJ, Zimmer JT, Maeda T, Simon MD, Crews CM. Swartzel JC, et al. Among authors: zimmer jt. ACS Chem Biol. 2022 Jul 15;17(7):1789-1798. doi: 10.1021/acschembio.2c00145. Epub 2022 Jun 24. ACS Chem Biol. 2022. PMID: 35749470 Free PMC article.